Natural Scaffolds Review Podcast

Cryogels with Sandeep Koshy

Hydrogels have been used successfully in many tissue engineering applications.  However, because they are inherently soft materials, it is not always easy to get the large, interconnected pore network that enhances cell behavior and allows neovascularization of implants.  Many techniques have been developed to try and create pore networks after the gelling process completes, like using salt or sugar porogens.  But porogens must be removed to create the pore network, and the removal process has always been the Achilles heel…

Decellularized Organs with Giuseppe Orlando

All tissue engineering and regenerative medicine scaffolds try to mimic some characteristic of the natural extracellular matrix, or ECM.  It supports growth of blood vessels, nerves, and allows sufficient diffusion of nutrients to keep native tissue healthy.  Usually scientists and engineers try to isolate just a few of the characteristics of the ECM, such as mechanical properties, three dimensional structure, and inclusion of proteins or other functional molecules. A few researchers have decided to not to mimic ECM and instead…

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